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KMID : 0613820120220111552
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Journal of Life Science
2012 Volume.22 No. 11 p.1552 ~ p.1557
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Regulation of Pipernonaline on Biological Functions of Human Prostate Cancer Cells Based on Microarray Analysis
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Kim Sang-Hun
Kim Kwang-Youn
Yu Sun-Nyoung
Park Seul-Ki
Kwak In-Seok
Rhee Moon-Soo
Bang Byung-Ho
Chun Sung-Sik
Ahn Soon-Cheol
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Abstract
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It has been reported that pipernonaline isolated from Piper longum Linn. has a wide biochemical and pharmacological effect, including antitumor activity in prostate cancer PC-3 cells. However, its mechanism and expression pattern of many genes involved in biological functions are not clearly understood. To perform the gene expression study in PC-3 cells treated with pipernonaline, a cDNA microarray chip composed of 44,000 human cDNA probes was used. As a result, cell cycle-related genes, apoptosis-related genes, and cell proliferation/growth-related genes have been identified in gene ontology of the DAVID database. These results suggest that pipernonaline has antitumor activity by regulating the expression pattern of genes involved in biological signaling pathway in prostate cancer PC-3 cells. Further, additional analysis of these microarray data can be a useful tool to identify the mechanism and discovery of novel genes in cancer therapy.
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KEYWORD
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Pipernonaline, PC-3 cells, microarray, expression, cell cycle, apoptosis, proliferation
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